How Spravato works for Depression: Benefits, Side Effects & Where to get it

Spravato (esketamine) is an innovative treatment that is designed to help adults suffering from treatment-resistant depression. Spravato is a nasal spray that uses esketamine, a compound derived from ketamine, and is specifically made to help depression. More traditional treatments for depression mainly work by targeting serotonin levels, but Spravato has been formulated to target the glutamate system. This system is significant to how brain cells communicate and affect mood regulation. The nasal spray is given to patients under medical supervision. For many people, this cutting-edge treatment is a great step toward finding relief.

How Exactly Does Spravato Work?

Spravato specifically targets the N-methyl-D-aspartate (NMDA) receptors within the glutamate system. When activating these receptors, esketamine helps to repair and restore synaptic connections in the brain that were previously damaged in those suffering from depression. This restoration process is what ultimately helps improve mood, alleviate depression symptoms, and provide cognitive benefits for patients.

What Should I Expect During Treatment?

These treatments are given under medical supervision in a clinical setting to ensure safety. Here is what to expect:

• Administration: The nasal spray is self-administered by the patient with a healthcare professional present. The patient will spray each nostril to deliver the medicine most effectively. The doctor will inform the patient of the intended dosage.
• Duration: You can expect the session to last around 2 hours. This includes the time it takes to administer the spray and the monitoring afterward to ensure there are no significant side effects. Patients also need to have someone there to drive them home after treatment.
• Frequency: The recommended dosage is twice a week for 4 weeks. As the treatment progresses the frequency changes to once a week, or bi-weekly, for some patients.
• Monitoring: After the session, patients are observed for side effects like dizziness, nausea, or dissociation. Professionals will carefully monitor patients to ensure the treatment is safe and effective.

How Long Does It Take to Work?

The most compelling aspect of Spravato is how quickly it starts working. Many patients even start noticing improvements within 24 to 48 hours after their first treatment. This is very different when compared to traditional antidepressants, which can take weeks before noticing any improvement in symptoms. There have also been studies showing that when Spravato is combined with an oral antidepressant it can lead to a significant reduction in depressive symptoms. With long-term treatment, patients can help sustain these benefits over time.

Potential Side Effects and Risks

Like any other treatment, Spravato still has potential side effects. The most common side effects are as follows:

• Dizziness
• Nausea
• Feeling detached from reality (dissociation)
• Increased blood pressure
• Sleepiness

These side effects do not normally last long, but it’s important for patients to be monitored after administering the nasal spray. Serious side effects are rare but could include an increase in suicidal thoughts. Clinics take extra precautions to ensure safety, which include thorough screenings before the treatment and close monitoring afterward.

Who Is a Candidate for Spravato?

Spravato is a treatment specifically for adults with treatment-resistant depression (TRD). This means that they have tried at least two different oral antidepressants without any significant relief. However, not everyone is a candidate. You must consult with a healthcare provider to determine if Spravato is the right option for you. Although, you should not take Spravato if any of these apply:

• You are allergic to esketamine, ketamine, or any of its ingredients
• You have blood vessel issues, history of brain bleeding, or an abnormal blood vessel connection
• You are pregnant or breastfeeding

Preparing For Your First Visit

Starting Spravato can feel overwhelming, but a little preparation can make the experience smoother:

• Use MDDCare: MDDCare allows you to search by location and treatment type, helping you easily find a clinic that offers Spravato near you.
• Talk To Your Provider: Make sure you ask questions about the process, side effects, and what to expect.
• Arrange Transportation: You will need someone to drive you home after treatment since dizziness can be a temporary side effect.
• Plan To Rest: After your session, set aside time to rest, as you may feel tired or lightheaded. 

Spravato is a game-changer for those with treatment-resistant depression. If you or someone you know is exploring treatment options, Spravato could be the breakthrough you’ve been waiting for. Reach out to a trusted clinic to learn more about Spravato and start your recovery journey.